Granulation and encapsulation of N-Acetylcysteine (NAC) by internal phase separation

The encapsulation of small hydrophilic molecules offers advantages for the delivery food supplements and ingredients. These include: masking off-flavors, reducing astringency , controlling release profiles. We used an internal phase separation (IPS) method simultaneous granulation a supplement in corn oil. To prove that IPS is suitable with controllable times, we nutritional N -acetylcysteine (NAC) as our model molecule. NAC has variety health pharmaceutical benefits however it suffers from poor organoleptic properties such bitter aftertaste, astringency, strong sulfur smell. to produce free-flowing granules containing 56–78% diameters ranging 100 1000 μm. All materials this process were either safe or generally recognized (GRAS). granulated/encapsulated samples characterized using FTIR, NMR, SEM, LC-MS methods confirm presence unreacted high loading concentrations. kinetics was then monitored conductometry. combination carboxymethyl cellulose sodium salt (CMC) hydroxypropyl methylcellulose (HPMC) gums hydrophobic coating ethyl (EC), provided effective barrier ensure 5 min time window dispersion into water drinks before capsule starts dissolve loses more than 30 wt % its total loading. • Internal encapsulation. Using all GRAS materials, granulated encapsulated samples, showed delayed water. spherical can be ready-to-mix product.